The star was convinced the 2005 comedy would be her big break in Hollywood, but her portrayal of needy Gloria Cleary failed to lead to big opportunities, and she spent months fighting for work, auditioning three times a day.
However, Fisher, who is married to British comedian Sacha Baron Cohen, admits she's glad she didn't actually land any of the jobs she tried out for.
She tells Women's Health magazine, ""After doing that (Wedding Crashers), I had 12 months where I was auditioning three times a day and I didn't get a single job. That was a real low point.
""But with hindsight, those movies turned out to be awful, so I dodged a bullet. If I'd got any of them, I wouldn't be where I am today.""
Fisher has since gone on to star in films like Confessions of a Shopaholic and animated hits Horton Hears a Who! and Rango, while she also co-stars with Leonardo DiCaprio in director Baz Luhrmann's upcoming adaptation of literary classic The Great Gatsby.
And she insists she is pleasantly surprised with any success she achieves in Hollywood because she never had the self-confidence many young actors possess.
She says, ""I never had the chutzpah to just come to L.A. and make it. I didn't have that confidence. I'm always surprised when I get a job.""