More than 100 firefighters were called to tackle the blaze at the huge complex, which includes a back lot, a 400-seat theatre, five sound stages and a gym.
Although no one is thought to have been injured in the fire, part of the building collapsed before emergency officials managed to contain it.
Perry has yet to comment on the incident, but Winfrey, who co-executive produced 2009 movie Precious with the filmmaker, reveals he managed to remain calm and collected throughout the chaos of the blaze and showed ""real grace"" while handling the situation.
In a series of Twitter.com posts on Wednesday (02May12), she writes, ""my friend and younger big brother @tylerperry; his backlot studio was damaged by fire last night.
""His attitude in the midst of it all was calm and feeling blessed no one was injured. Real Grace under fire"".
Investigators have yet to establish the cause of the fire.